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KMID : 0613820070170111539
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Journal of Life Science
2007 Volume.17 No. 11 p.1539 ~ p.1546
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Antiinflammatory and Myocardial Protective Effects of Magnesium in Patients Undergoing Valvular Heart Surgery
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Moon Sung-Min
Hyun Kyung-Yae
Choi Seok-Cheol
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Abstract
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We have investigated whether the supplement of magnesium to cold blood cardioplegia improves myocardial protection. Sixty patients scheduled for elective valvular heart surgery were randomly assigned to a control group (n=30) which received conventional cold blood cardioplegia and an Mg group (n=30) which received cold blood cardioplegia supplemented with 2 g of magnesium sulfate. Electrolytes levels including Mg++, hematological and biochemical variables, cytokines, myocardial marker levels, and postoperative outcomes were compared between two groups before, during or after operation. Mg++ and Ca++ levels in the Mg group were higher than those of the control group after surgery. The total WBC counts, CK-MB, troponin-I and Interleukin-6 levels in the Mg group were lower than those of the control group after surgery. Postoperative incidence of atrial fibrillation was lower in the Mg group compared with the control group. These results showed that Mg++ attenuated inflammatory reaction, myocardial damage, and hypomagnesemia during valvular surgery and reduced postoperative arrhythmia incidence without side effects.
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KEYWORD
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Heart surgery, magnesium, cardioplegia
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